From the Northwest (Erie)
- Interstate 79 South to Rte. 422 East
- Rte. 422 East to the Oakland Avenue exit (Rte 286)
- Turn left on Oakland Avenue to IUP
From the Northeast (Scranton)
- Interstate 80 West to Rte. 220 South
- Rte. 220 South to Altoona
- Rte. 220 to Rte. 22 West to Ebensberg
- Rte. 422 West to IndianaTake the Oakland Ave. Exit (Rte. 286)
- Turn right on Oakland Avenue to IUP
From: the Southwest (Pittsburgh)
- Rte. 22 East to the Indiana Exit
- Rte. 119 North to Indiana
- Take Rte. 422 West
- Take Oakland Avenue exit (Rte. 286)
- Turn right on Oakland Ave. to IUP
From: the Southeast (Harrisburg)
- Turnpike West to Bedford (exit 11)
- Rte. 220 North toward Altoona
- Rte. 22 West to Ebensburg
- Rte. 422 West to Indiana
- Take the Oakland Ave. exit (286)
- Turn right on Oakland Ave. to IUP
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